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"Our work challenges the textbook model of how the brain fuels itself. Neurons are extra self-enough than we thought," Singh said. Co-author Daniel Col髇-Ramos, the Dorys McConnell Duberg Professor of Neuroscience and Cell Biology at YSM, said the examine helps the notion of glycogen as an "energy capacitor" in neurons. "Just like in muscles, this reserve can buffer rapid shifts in power demand," Col髇-Ramos mentioned. Other authors, all from Yale, embrace Sarah Emerson, a postdoctoral researcher in neuroscience; Ian J. Gonzalez, a graduate scholar in cell biology; Anjali A. Vishwanath and Anastasia Tsives, post-doctoral researchers in neuroscience; and Richard Goodman, a analysis scientist in neuroscience. Original Research: Open access. "Glycogen helps glycolytic plasticity in neurons" by Milind Singh et al. Glycogen is the biggest vitality reserve in the brain, however the particular position of glycogen in supporting neuronal vitality metabolism in vivo will not be nicely understood. We performed an RNAi display and identified that PYGL-1, an ortholog of the human glycogen phosphorylase, is required in neurons for glycolytic plasticity. We determined that neurons make use of at the least two mechanisms of glycolytic plasticity: glycogen-dependent glycolytic plasticity (GDGP) and glycogen-impartial glycolytic plasticity. We uncover that GDGP is employed underneath circumstances of mitochondrial dysfunction, reminiscent of transient hypoxia or in mutants for mitochondrial perform.

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